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KMID : 0043320080310050606
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Archives of Pharmacal Research
2008 Volume.31 No. 5 p.606 ~ p.610
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Meso-Dihydroguaiaretic Acid Isolated from Saururus chinensis Inhibits Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells
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Moon Tae-Chul
Seo Chang-Seob
Ha Kyung-Mi
Kim Jin-Cheul
Hwang Nam-Kyung
Hong Tae-Gyun
Kim Jee-Hyeun
Kim Do-Hun
Son Jong-Keun
Chang Hyun-Wook
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Abstract
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Meso-dihydroguaiaretic acid (MDGA) is a medicinal herbal product isolated from the aerial parts of Saururus chinensis that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin generation in bone marrow-derived mast cells (BMMC) (). However, this compound did not inhibit COX-2 protein expression in BMMC at concentrations up to , indicating that MDGA directly inhibits COX-2 activity. In addition, this compound consistently inhibited the production of leukotriene . These results demonstrate that MDGA inhibits both COX-2 and 5-lipoxygenase. Furthermore, this compound strongly inhibited the degranulation reaction in BMMC (. Therefore, this compound might provide a basis for novel anti-inflammatory drug development.
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KEYWORD
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Saururus chinensis, Meso-Dihydroguaiaretic acid, Cyclooxygenase-2, 5-Lipoxygenase, Degranulation, Bone marrow-derived mast cells
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